What is XLSX?

A modern Excel workbook, which is really a zip full of XML. Unlike a CSV it knows what a number is, holds multiple sheets, and keeps formulas and formatting. It's what people mean when they say 'send me a spreadsheet'.

What is XML?

Verbose, strict, and still holding up enormous amounts of the world - government feeds, financial messaging, publishing, office documents. JSON took the web from it, but anywhere with schemas and validators and twenty years of history, XML is what's on the wire.