What is XLSX?

A modern Excel workbook, which is really a zip full of XML. Unlike a CSV it knows what a number is, holds multiple sheets, and keeps formulas and formatting. It's what people mean when they say 'send me a spreadsheet'.

What is Markdown?

Plain text with just enough punctuation to imply formatting, which is why it ended up as the default for READMEs, issues, wikis and notes. Its tables are the awkward part - a pipe-and-dash grid that's readable enough written by hand and tedious to maintain by hand.